As a child, Herbert West watches his father Peter reanimate his dead mother Judith in a secret basement lab — only for Judith to mortally wound Peter and nearly kill Herbert before Peter shoots her. The trauma leaves its mark on Herbert, but so does one final image: his mother’s finger, twitching after death. Thirty years later, Herbert West is a brilliant, secretive surgeon still chasing his father’s obsession.

Pathologist Kate Locke arrives in town and is drawn into his orbit — first through a spark at a hospital fundraiser, then through his secret lab, where he reveals a serum capable of reanimating severed tissue. Kate, hiding a dark past of her own, is thrilled rather than horrified, and moves into West’s mansion to work alongside him. Their early experiments on a cadaver succeed only briefly. West concludes that dead tissue is the problem — they need something fresher.